Endocrine Abstracts

Objectives: In May 2016, the local thyroid cancer tumor group proposed and adopted specific thyroid lobectomy recommendations based on the 2015 ATA guidelines. ThyroSPEC molecular testing was introduced for all Bethesda III and IV lesions in August 2020. The goal of this study was to evaluate the implementation of the ATA lobectomy guidelines and the introduction of ThyroSPEC molecular testing on rates of upfront total thyroidectomy (TTx), diagnostic lobectomy for Bethesda I-I...

Objectives: Molecular diagnostic tests for indeterminate thyroid nodules (ITNs) are marketed based on negative predictive value (NPV) and benign call rate. Arguments that unnecessary surgeries are avoided based on NPV/BCR incorrectly assume that all ITNs would undergo diagnostic surgery in the absence of molecular testing. In our practice with centralized triage and cytopathology the resection and malignancy rate, respectively, were 21% and 26% for AUS/FLUS and 56% and 43% for...

Objective: The specificity and cellular origin of the SSRS findings in CN, HN, PC and GD is currently unclear and partially contradicts the well defined action of somatostatin on thyroid cell signaling. Therefore, we systematically evaluated SSTR2 expression in benign cold (CN) and hot thyroid nodules (HN), papillary carcinomas (PCs) and Graves’ disease (GD) in comparison with intraindividual control surrounding tissues (ST) by means of immunohistochemistry.<p class="...

Introduction: Two-thirds of metastatic differentiated thyroid cancer (DTC) patients have RAI-resistant disease, resulting in poor prognosis and high disease-related mortality. Current studies of individualized therapy with different MAPK inhibitors report restoring RAI-avidity in 50 – 70% of BRAF and RAS mutated and thyroid cancers with no detected driver mutation. Five recent case reports of rare NTRK and RET-PTC fusion-positive metast...

Introduction: Follicular adenomas (FTA) and carcinomas (FTC) are thyroid tumours that are indistinguishable in the fine needle aspiration biopsy (FNAB). In our previous research we concentrated on post-operative material and developed the classifier, which discriminates the FTC and FTA, based on formalin-fixed paraffin-embedded (FFPE) material. The classifier was based on expression of five genes and gave the promising sensitivity of 71% and specificity of 72%. The aim of the ...